Vitamin A derivatives that speed skin cell turnover. Prescription tretinoin has the strongest evidence for acne and sun damage.
Caution
Can irritate and increase sun sensitivity. Oral retinoids and high-dose vitamin A are not for pregnancy.
Evidence & sources
Topical retinoids are recommended as a core treatment for acne. Evidence: strong. Known: Clinical guideline based on trials. Unknown: Prescription retinoids are not recommended in pregnancy. Source: American Academy of Dermatology (Zaenglein et al., JAAD), Guidelines of care for the management of acne vulgaris (2016).